Endocrine Abstracts

Background and objectives: Our objective in this study was to discover the relationship of irisin hormone, which acts on adipose tissue and the metabolism as thyroid hormones, with the thyroid functions and the obesity secondary to thyroid disease.Methods: A total of 74 patients were included in the study, of the patients, 37 were newly diagnosed with Hashimoto’s thyroiditis dependent hypothyroidism but not received a treatment yet, and the remainin...

Background: Procalcitonin (PCT) is often an increased acute phase reactant in the bacterial infection-related inflammation, and its serum level is reported elevated in several autoimmune disease. However, the level of PCT and its relationship with autoimmunity remain unknown in Hashimoto’s thyroiditis (HT). Our objective was to investigate the serum levels of PCT and its association with autoantibodies in patients with euthyroid HT.Methods: A total ...

Aims: We aimed to determine the irisin level in patients with type 1 diabetes mellitus (T1DM) and to examine the relation of irisin level with inflammation and autoimmunity.Methods: This study included 35 cases diagnosed with T1DM and 36 healthy volunteers. Anti-glutamic acid decarboxylase (Anti-GAD), islet cell antibody (ICA), insulin autoantibody levels of the patients have been measured at the time they were included in the study and were recorded fro...

Objective: To investigate dynamic thiol/disulphide homeostasis in autoimmune subclinical hypothyroidism.Materials and methods: 48 patients with newly diagnosed subclinical hypothyroidism due to Hashimoto’s thyroiditis and not yet on any treatment and 48 healthy subjects without any known disease were enrolled. Thiol/disulfide homeostasis (native thiol(-SH)–disulphide(-S-S-) exchanges) was measured in both groups with new method developed by Ere...

Objective: We aimed to investigate the effects of oxidative stress in the pathhogenesis and progression of thyroiditis in patients with Hashimoto’s thyroiditis whose aetiopathogenesis includes environmental and genetic factors.Methods: 80 patients (40 euthyroid and 40 subclinical hypothyroidism) older than 18 years with newly diagnosed Hashimoto’s thyroiditis and not yet on any treatment were enrolled. Patients were followed up for 9 months. Bl...

Background and objectives: Our objective in this study was to discover the relationship of irisin hormone, which acts on adipose tissue and the metabolism as thyroid hormones, with the thyroid functions and the obesity secondary to thyroid disease.Methods: A total of 74 patients were included in the study, of the patients, 37 were newly diagnosed with Hashimoto’s thyroiditis dependent hypothyroidism but not received a treatment yet, and the remainin...

Objective: Thiols are organic compounds that contain sulphydryl group (-SH) and have important role in preventing oxidative stress especially in cells. The aim of our study is to investigate the relationship between hypothyroidism due to HT and the thiol disulfide homeostasis, the effect of treatment on this homeostasis and to demonstrate the utility of thiol/disulphide homestasis as a marker for assessing the damage to functional group of proteins and the oxidative balance in...

Background: Thiol/disulfide homeostasis plays an important role in antioxidative defense mechanism, detoxification, signal transport, management of enzyme activity and trascription factors, and apoptosis. When thiol/disulphide homeostasis breaks down, these important cellular functions get deranged. Pathologies secondary to oxidative stress are seen in organeles in which this homeostasis is deranged. The aim of the study was to investigate dynamic thiol/disulfide homeostasis i...

Introduction: Hypogonadism have major affect on urogenital system also have several affect on other systems like cardiovascular and skeletal systems. There are very few study conducted on markers of atherosclerosis such as flow mediated dilatation (%FMD), carotis intima-media thickness(CIMT) and adipocytokine levels in idiopatic hypogonadotropic hypogonadal(IHH) males. The aim of this study was to evaluate this atherosclerotic risk factors in adult IHH male.<p class="abste...